2021

January 29

 * Officials held a ribbon-cutting ceremony for a new spur line connecting the Longleaf Trace north to East 4th Street and East 6th Street

February 7

 * An early morning fire destroyed the original Hattiesburg High School gym near Hawkins Elementary School

February 25

 * Hattiesburg officials unveiled plans to create Gordon’s Creek Commons on McLeod Street in downtown Hattiesburg

February 26

 * Nannie Mac's expanded into the building next door, opening a coffee shop in the former Fourth Street CrossFit building

March 5

 * A new mural called "Courage" was unveiled at Veteran's Memorial Park in downtown Hattiesburg

March 26

 * A ribbon-cutting ceremony was held for the a new multi-use venue called Southern Station on the campus of USM
 * A ribbon-cutting ceremony was held for the King Student Center on the campus of William Carey University

March 30

 * Officials unveiled a new USM-themed fire engine named "Screaming Eagle"

May 4

 * A small twin-engine airplane crashed into a home on Annie Christie Drive, killing all three passengers and an occupant of the house

May 15

 * The Hattiesburg Zoo opened its expanded Africa exhibit, featuring two giraffes, Sue Ellen and Alberta

May 17

 * Officials held a ribbon-cutting ceremony for the extension of the walking trail around Duncan Lake

May 25

 * Officials held a "hose-cutting" ceremony for the new Fire Station 9 on Irby Road just off Highway 49

May 27

 * Officials held a dedication ceremony for a portion of Highway 49, from the intersection of Hardy Street to one mile north, to designated it as the "Clyde Kennard Memorial Highway" after Senate Bill 2481 was signed on March 17

May 29

 * A new splash pad opened at Dewitt Sullivan Park in Palmer's Crossing

June 1

 * A new mural called "Welcome to Midtown" was unveiled on the east side of the Midtown Market building

June 9

 * Toby Barker was reelected mayor of Hattiesburg. Council members Jeffrey George and Carter Carroll were releected to the City Council, and Dave Ware defeated incumbent Mary Dryden. Council members Nicholas Brown and Deborah Delgado were unopposed.

July 22

 * Nick's Ice House on Hardy Street was destroyed in a fire that broke out around midnight

July 30

 * William Carey University officials held a ribbon-cutting ceremony for the new College of Health Sciences building

August 4

 * Raising Cane's moved to its new location on Hardy Street in the lot formerly occupied by Applebee's, just west of its original location

August 17

 * The city council voted to approve Peggy Sealy's nomination as police chief

September 21

 * The city council voted to declare both Club Empire on Timothy Lane and Roper's Rockin' Country on Highway 49 as nuisances

October 19

 * The city council unanimously voted to allow the old Forrest Hotel to become a residential apartment building

October 21

 * Peggy Sealy was sworn in as the first female police chief of the Hattiesburg police department

October 24

 * South Mouth Deli closed

October 26

 * USM announced it was leaving Conference USA and joining the Sun Belt Conference

October 27

 * Construction began on a new roundabout at the intersection of Hardy Street, Green Street, 2nd Street, and Adeline Street

November 1

 * Officials at the Hattiesburg Zoo held a ribbon cutting for a new giraffe feeding station

November 16

 * The Hattiesburg city council voted to rezone the area around the former Calico Antique Mall to allow the building to be renovated into a food court, bar, and office space

November 19

 * Officials held a ribbon-cutting ceremony for a new mural called "Together As One," on the Longleaf Trace at the intersection of 4th Street and North 38th Avenue

November 23

 * Hattiesburg officials announced that a $500,000 grant would be matched with city funds to create Midtown Green, a new 4.2 acre park on Crestmont Avenue in Midtown

December 6

 * Jones Capital announced it was going to build a new $40 million headquarters at The District at Midtown

Other
''These are events that don't have a specific known date
 * Avid Hotel opened on North 40th Avenue in January
 * The First Bank branch at 3101 Hardy Street became a BancorpSouth Bank branch in early 2021
 * The Sunflower grocery store at 1900 Hardy Street was rebranded as a Corner Market store in early 2021
 * Domino's Pizza moved from its location at 6061 Highway 98 to 6136 Highway 98 in mid 2021
 * A new Corner Market store opened in the former Winn-Dixie building in the Lincoln Square Shopping Center in mid 2021
 * Calico Antique Mall closed in July
 * Trattoria Pizzeria opened in November in the former Bianchi's Pizzeria building